YWHAEP2

Across TCGA pan-cancer cohorts, YWHAEP2 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated YWHAEP2 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher YWHAEP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated YWHAEP2 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

UCEC, HNSC, and STAD are the cancer types where YWHAEP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.257	0.840	<.001	102	view →
HNSC	DFS	Tertile	IV	0.328	0.650	.006	84	view →
STAD	OS	Tertile	All	0.188	0.569	.014	54	view →
OV	DFS	Tertile	II,III,IV	0.226	0.383	.033	36	view →
GBM	DFS	Tertile	All	0.473	0.222	.029	12	view →
COAD	OS	Tertile	All	0.181	0.805	.040	9	view →
ESCA	DFS	Tertile	All	0.293	0.542	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

YWHAEP2–UCEC (DFS)

Open the UCEC breakdown →