Across TCGA pan-cancer cohorts, YTHDF3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated YTHDF3 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher YTHDF3 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated YTHDF3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUAD, and COAD are the cancer types where YTHDF3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.318	.005	34	view →
LUAD	OS	Median	All	0.288	0.813	<.001	21	view →
COAD	OS	Median	All	0.159	0.799	.003	18	view →
KIRC	OS	Median	All	0.178	0.655	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: YTHDF3 tumor-vs-normal RNA expression · all YTHDF3 data types