Across TCGA pan-cancer cohorts, YTHDF3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated YTHDF3 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher YTHDF3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated YTHDF3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, COAD, and HNSC are the cancer types where YTHDF3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.869	0.207	.001	50	view →
COAD	DFS	Median	III,IV	1.000	0.895	.038	12	view →
HNSC	DFS	Median	IV	0.704	0.899	.010	4	view →
CCRCC	OS	Quartile	All	0.887	1.000	.040	3	view →
LSCC	OS	Quartile	All	0.896	0.654	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: YTHDF3 tumor-vs-normal RNA expression · all YTHDF3 data types