Across TCGA patient cohorts, YTHDF3 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,310 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible YTHDF3-associated proteins across cancer lineages are RAB2A, ARFGEF1, and TCEA1. Each is linked with YTHDF3 in more than 5 cancer types. Because this analysis shows association rather than direction, both YTHDF3-to-partner and partner-to-YTHDF3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF3→partner) and Y-score (partner→YTHDF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAB2A →	+0.410	+0.817	.001	<.001	3	6
BRCA	ARFGEF1 →	+0.489	+0.502	<.001	<.001	3	5
LSCC	TCEA1 →	+0.363	+0.501	<.001	<.001	3	5
LSCC	NCOA2 →	+0.294	+0.449	<.001	<.001	3	4
LSCC	RBM12B →	+0.176	+0.350	.002	.001	3	4
LSCC	TMEM68 →	+0.454	+0.612	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,310 associations by consensus.

Exploration

YTHDF3 survival (RNA) · tumor vs normal (RNA) · all YTHDF3 data types