Across TCGA patient cohorts, YTHDF3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YTHDF3-associated genes across cancer lineages are Rad50, ATM, and Cyclin-D1. Each is linked with YTHDF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDF3-to-partner and partner-to-YTHDF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF3→partner) and Y-score (partner→YTHDF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.184	-1.440	.028	.024	3	2
UCEC	ATM →	-0.424	-1.700	.007	.042	3	2
UCEC	Cyclin-D1 →	+0.115	+2.000	.039	.029	3	2
UCEC	EGFR_pY1068 →	-0.245	-1.440	.004	.024	3	1
UCEC	eIF4E →	+0.185	+2.415	.011	.003	3	1
UCEC	FoxM1 →	+0.215	+1.736	.016	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

YTHDF3 survival (RNA) · tumor vs normal (RNA) · all YTHDF3 data types