Across TCGA cell cohorts, YTHDF3 mutation is significantly associated with the RNA expression of many other genes, with 394 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YTHDF3-associated genes across cancer lineages are GCAT, EIF3L, and DEPDC5. Each is linked with YTHDF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDF3-to-partner and partner-to-YTHDF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF3→partner) and Y-score (partner→YTHDF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.342	+3.169	<.001	.006	3	1
LARGE_INTESTINE	EIF3L →	+0.578	+3.389	.001	.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.721	+3.364	<.001	.002	3	1
LARGE_INTESTINE	MCAT →	+0.709	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TNRC6B →	+0.982	+3.234	<.001	.004	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.727	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 394 associations by consensus.

Exploration

YTHDF3 survival (RNA) · tumor vs normal (RNA) · all YTHDF3 data types