Across TCGA patient cohorts, YTHDF2 mutation is significantly associated with the RNA expression of many other genes, with 1,559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YTHDF2-associated genes across cancer lineages are HK2, FCRL3, and EOMES. Each is linked with YTHDF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDF2-to-partner and partner-to-YTHDF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF2→partner) and Y-score (partner→YTHDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HK2 →	+0.793	+4.247	<.001	<.001	3	2
UCEC	FCRL3 →	+0.433	+3.180	<.001	<.001	3	2
UCEC	EOMES →	+0.687	+3.609	<.001	.001	3	2
UCEC	CHCHD4 →	+0.409	+2.724	.002	.003	3	2
UCEC	PYHIN1 →	+0.827	+3.716	<.001	<.001	3	2
UCEC	TSR1 →	+0.484	+2.502	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,559 associations by consensus.

Exploration

YTHDF2 survival (RNA) · tumor vs normal (RNA) · all YTHDF2 data types