Across TCGA cell cohorts, YTHDF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,356 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YTHDF2-associated GO terms across cancer lineages are Regulation of chromosome condensation, Regulation of DNA stability, and Endothelial to hematopoietic transition. Each is linked with YTHDF2 in more than 12 cancer types. Because this analysis shows association rather than direction, both YTHDF2-to-partner and partner-to-YTHDF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF2→partner) and Y-score (partner→YTHDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of chromosome condensation →	+0.206	+0.643	<.001	<.001	3	13
BONE	Regulation of DNA stability →	+0.158	+0.772	<.001	.002	3	13
CNS	Endothelial to hematopoietic transition →	+0.095	+0.306	<.001	.007	3	13
BONE	Nuclear pore complex assembly →	+0.158	+0.719	.001	<.001	3	13
BLOOD_Leukemia	Negative regulation of cell cycle process →	+0.055	+0.412	<.001	<.001	3	12
BONE	Transcription elongation-coupled chromatin remodeling →	+0.137	+0.791	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,356 associations by consensus.

Exploration

YTHDF2 survival (RNA) · tumor vs normal (RNA) · all YTHDF2 data types