YTHDF1

Across TCGA pan-cancer cohorts, YTHDF1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated YTHDF1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher YTHDF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated YTHDF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

HNSC, LUAD, and COAD are the cancer types where YTHDF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.286	0.834	.008	36	view →
LUAD	DFS	Median	III,IV	0.805	0.247	.001	28	view →
COAD	DFS	Median	All	1.000	0.923	.023	18	view →
CCRCC	OS	Quartile	III,IV	0.043	0.985	.025	15	view →
PDAC	OS	Tertile	III,IV	0.718	0.168	.005	13	view →
GBM	OS	Tertile	All	0.978	0.799	.013	3	view →
LSCC	DFS	Median	All	0.955	0.915	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

YTHDF1–HNSC (DFS)

Open the HNSC breakdown →