YTHDF1

Across TCGA patient cohorts, YTHDF1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,387 significant associations in total. GBM shows the largest number of these associations.

The most reproducible YTHDF1-associated genes across cancer lineages are RAE1, MRGBP, and GID8. Each is linked with YTHDF1 in more than 7 cancer types. Because this analysis shows association rather than direction, both YTHDF1-to-partner and partner-to-YTHDF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, YTHDF1 versus RAE1 in UCEC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF1→partner) and Y-score (partner→YTHDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAE1 →	+0.712	+0.307	<.001	<.001	3	8
UCEC	MRGBP →	+0.931	+0.256	<.001	<.001	3	8
LSCC	GID8 →	+0.563	+0.255	<.001	<.001	3	8
GBM	VAPB →	+0.625	+0.335	<.001	<.001	3	8
OV	STAU1 →	+0.506	+0.303	.002	<.001	3	8
OV	LSM14B →	+0.672	+0.378	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,387 associations by consensus.

YTHDF1 vs RAE1 — UCEC

Explore this scatter interactively →