YTHDF1

Across TCGA patient cohorts, YTHDF1 mutation is significantly associated with the RNA expression of many other genes, with 2,016 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YTHDF1-associated genes across cancer lineages are RNU6-14P, CHP1P3, and MIR8053. Each is linked with YTHDF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both YTHDF1-to-partner and partner-to-YTHDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-14P grouped by YTHDF1-low versus YTHDF1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF1→partner) and Y-score (partner→YTHDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-14P →	+0.440	+5.669	<.001	.003	3	3
SKCM	CHP1P3 →	+0.051	+3.095	.003	.007	3	3
CESC	MIR8053 →	+0.587	+6.342	<.001	.001	3	2
UCEC	ZNHIT3 →	+0.327	+1.606	.009	.006	3	2
UCEC	TAF9 →	+0.709	+2.201	<.001	<.001	3	2
UCEC	RNA5SP414 →	+0.498	+2.177	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,016 associations by consensus.

RNU6-14P by YTHDF1 expression — CESC

Explore this box plot interactively →