YTHDF1

Across TCGA patient cohorts, YTHDF1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YTHDF1-associated genes across cancer lineages are Notch1, p62 Lck ligand, and Cyclin-B1. Each is linked with YTHDF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDF1-to-partner and partner-to-YTHDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by YTHDF1-low versus YTHDF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF1→partner) and Y-score (partner→YTHDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.152	+2.013	.003	.016	3	2
UCEC	p62 Lck ligand →	+0.438	+2.736	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.429	+2.459	.037	.019	3	2
UCEC	EGFR_pY1068 →	-0.190	-2.115	.039	.017	3	1
UCEC	eIF4E →	+0.158	+2.472	.041	.010	3	1
UCEC	MEK1 →	+0.304	+2.222	.023	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Notch1 by YTHDF1 expression — UCEC

Explore this box plot interactively →