YTHDF1

Across TCGA cell cohorts, YTHDF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,467 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YTHDF1-associated GO terms across cancer lineages are Promoter clearance during DNA-templated transcription, RNA polymerase II promoter clearance, and Regulation of RNA splicing. Each is linked with YTHDF1 in more than 14 cancer types. Because this analysis shows association rather than direction, both YTHDF1-to-partner and partner-to-YTHDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Promoter clearance during DNA-templated transcription grouped by YTHDF1-low versus YTHDF1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF1→partner) and Y-score (partner→YTHDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Promoter clearance during DNA-templated transcription →	+0.119	+0.592	<.001	<.001	3	14
KIDNEY	RNA polymerase II promoter clearance →	+0.119	+0.592	<.001	<.001	3	14
BONE	Regulation of RNA splicing →	+0.100	+0.736	<.001	<.001	3	14
STOMACH	Regulation by virus of viral protein levels in host cell →	+0.196	+0.862	<.001	<.001	3	14
SKIN	Positive regulation by virus of viral protein levels in host cell →	+0.097	+0.512	.003	.002	2	15
BONE	Negative regulation of t-circle formation →	+0.113	+0.695	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,467 associations by consensus.

Promoter clearance during DNA-templated transcription by YTHDF1 expression — KIDNEY

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