YTHDF1

Across TCGA cell cohorts, YTHDF1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible YTHDF1-associated genes across cancer lineages are OR56A5, OR6V1, and IL31. Each is linked with YTHDF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDF1-to-partner and partner-to-YTHDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by YTHDF1-low versus YTHDF1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF1→partner) and Y-score (partner→YTHDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR56A5 →	+0.060	+3.342	<.001	.008	3	2
BLOOD_Lymphoma	OR6V1 →	+0.017	+3.584	<.001	.004	3	2
SKIN	IL31 →	+0.032	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	ECE2 →	+0.045	+3.736	<.001	.008	3	1
BLOOD_Lymphoma	PANX3 →	+0.223	+4.212	<.001	.002	3	1
BLOOD_Lymphoma	TMEM190 →	+0.164	+3.584	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR56A5 by YTHDF1 expression — BLOOD_Lymphoma

Explore this box plot interactively →