YTHDF1

Across TCGA cell cohorts, YTHDF1 mutation is significantly associated with the mutation status of many other genes, with 2,941 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YTHDF1-associated genes across cancer lineages are KLHL1, HNF4G, and EHMT1. Each is linked with YTHDF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both YTHDF1-to-partner and partner-to-YTHDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL1 grouped by YTHDF1-low versus YTHDF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF1→partner) and Y-score (partner→YTHDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLHL1 →	+1.807	+3.087	.001	.001	1	4
BLOOD_Lymphoma	HNF4G →	+5.554	+4.584	<.001	<.001	1	4
LARGE_INTESTINE	EHMT1 →	+1.691	+2.479	.008	.008	1	4
LARGE_INTESTINE	FCGBP →	+1.707	+2.991	.002	.002	1	4
SKIN	HYAL4 →	+5.977	+5.977	<.001	<.001	1	4
SKIN	ADAMTS19 →	+3.655	+4.906	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,941 associations by consensus.

KLHL1 by YTHDF1 expression — LARGE_INTESTINE

Explore this box plot interactively →