YTHDC2

Across TCGA patient cohorts, YTHDC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,853 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible YTHDC2-associated proteins across cancer lineages are PHAX, YTHDC2_S1279, and DMXL1. Each is linked with YTHDC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both YTHDC2-to-partner and partner-to-YTHDC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, YTHDC2 versus PHAX in GBM, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC2→partner) and Y-score (partner→YTHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PHAX →	+0.402	+0.357	<.001	<.001	3	5
PDAC	YTHDC2_S1279 →	+0.709	+0.318	<.001	<.001	3	5
COAD	DMXL1 →	+0.335	+0.468	.002	<.001	3	5
BRCA	FBXO38 →	+0.452	+0.632	<.001	<.001	3	5
BRCA	RANBP3 →	+0.292	+0.800	<.001	<.001	3	4
GBM	NPM1 →	+0.439	+0.343	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,853 associations by consensus.

YTHDC2 vs PHAX — GBM

Explore this scatter interactively →