YTHDC2

Across TCGA patient cohorts, YTHDC2 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YTHDC2-associated genes across cancer lineages are INPP4B, TSC1, and 4E-BP1_pT70. Each is linked with YTHDC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both YTHDC2-to-partner and partner-to-YTHDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by YTHDC2-low versus YTHDC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC2→partner) and Y-score (partner→YTHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.529	-2.321	<.001	.032	3	3
COAD	TSC1 →	-0.359	-2.576	.001	.011	3	3
COAD	4E-BP1_pT70 →	+0.098	+2.593	.049	.006	3	3
UCEC	FoxM1 →	+0.182	+1.432	.017	.005	3	3
UCEC	NF-kB-p65_pS536 →	-0.308	-1.584	.021	.032	3	3
COAD	EGFR_pY1068 →	-0.433	-3.169	.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

INPP4B by YTHDC2 expression — COAD

Explore this box plot interactively →