YTHDC2

Across TCGA cell cohorts, YTHDC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,276 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YTHDC2-associated GO terms across cancer lineages are Cell cycle switching, mitotic to meiotic cell cycle, Cell cycle switching, and Nucleotide-excision repair. Each is linked with YTHDC2 in more than 16 cancer types. Because this analysis shows association rather than direction, both YTHDC2-to-partner and partner-to-YTHDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle switching, mitotic to meiotic cell cycle grouped by YTHDC2-low versus YTHDC2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC2→partner) and Y-score (partner→YTHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cell cycle switching, mitotic to meiotic cell cycle →	+1.177	+0.818	<.001	<.001	3	17
LUNG_SCLC	Cell cycle switching →	+1.177	+0.818	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Nucleotide-excision repair →	+0.086	+1.309	<.001	<.001	3	16
BREAST	Positive regulation of organelle assembly →	+0.065	+0.804	.001	.002	3	16
BONE	Microtubule polymerization →	+0.142	+0.791	<.001	<.001	3	16
BLOOD_Lymphoma	Nuclear export →	+0.095	+1.474	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,276 associations by consensus.

Cell cycle switching, mitotic to meiotic cell cycle by YTHDC2 expression — LUNG_SCLC

Explore this box plot interactively →