YTHDC2

Across TCGA cell cohorts, YTHDC2 mutation is significantly associated with the RNA expression of many other genes, with 365 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YTHDC2-associated genes across cancer lineages are MAGEB4, RBFA, and C12orf57. Each is linked with YTHDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDC2-to-partner and partner-to-YTHDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by YTHDC2-low versus YTHDC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC2→partner) and Y-score (partner→YTHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAGEB4 →	+0.019	+2.536	<.001	.009	3	2
LARGE_INTESTINE	RBFA →	+0.671	+2.502	.004	.005	3	2
LARGE_INTESTINE	C12orf57 →	+0.838	+3.169	.001	.009	3	2
LARGE_INTESTINE	HMGN4 →	+0.490	+2.502	.002	.005	3	2
LARGE_INTESTINE	MT-CO3 →	-0.945	-3.321	<.001	.002	3	2
LARGE_INTESTINE	SERPINB4 →	+0.323	+2.761	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 365 associations by consensus.

MAGEB4 by YTHDC2 expression — BLOOD_Leukemia

Explore this box plot interactively →