YTHDC1

Across TCGA pan-cancer cohorts, YTHDC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated YTHDC1 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher YTHDC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated YTHDC1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and LUAD are the cancer types where YTHDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	1.000	0.773	.036	18	view →
LSCC	OS	Tertile	All	0.920	0.696	.023	9	view →
LUAD	DFS	Tertile	III,IV	0.315	0.935	.017	6	view →
UCEC	OS	Tertile	All	0.925	1.000	.031	6	view →
HNSC	OS	Median	II,III,IV	0.991	0.935	.024	5	view →
GBM	OS	Quartile	All	0.694	0.312	.013	5	view →
CCRCC	OS	Median	All	0.730	1.000	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

YTHDC1–COAD (DFS)

Open the COAD breakdown →