YTHDC1

Across TCGA patient cohorts, YTHDC1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,637 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible YTHDC1-associated genes across cancer lineages are PRUNE1, POGZ, and IPO9. Each is linked with YTHDC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both YTHDC1-to-partner and partner-to-YTHDC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, YTHDC1 versus PRUNE1 in LSCC, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC1→partner) and Y-score (partner→YTHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRUNE1 →	+0.585	+0.235	<.001	<.001	3	7
HNSC	POGZ →	+0.795	+0.261	<.001	<.001	3	7
HNSC	IPO9 →	+0.820	+0.226	<.001	.003	3	7
HNSC	CXCR2 →	-0.979	-0.280	<.001	<.001	3	7
HNSC	MBTD1 →	+0.783	+0.314	<.001	<.001	3	6
BRCA	PRPF3 →	+0.598	+0.295	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,637 associations by consensus.

YTHDC1 vs PRUNE1 — LSCC

Explore this scatter interactively →