YTHDC1

Across TCGA patient cohorts, YTHDC1 mutation is significantly associated with the RNA expression of many other genes, with 2,480 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YTHDC1-associated genes across cancer lineages are CENPU, ZNF367, and PBK. Each is linked with YTHDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both YTHDC1-to-partner and partner-to-YTHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by YTHDC1-low versus YTHDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC1→partner) and Y-score (partner→YTHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.448	+1.327	.008	.006	3	3
UCEC	ZNF367 →	+0.576	+1.971	<.001	<.001	3	3
UCEC	PBK →	+0.585	+1.698	.005	<.001	3	3
COAD	PUSL1 →	+0.552	+3.459	.004	.005	3	3
UCEC	FAXDC2 →	-0.532	-2.574	<.001	<.001	3	3
COAD	ELP5 →	+0.573	+3.513	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,480 associations by consensus.

CENPU by YTHDC1 expression — UCEC

Explore this box plot interactively →