YTHDC1

Across TCGA patient cohorts, YTHDC1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YTHDC1-associated genes across cancer lineages are FASN, XBP1, and ACC1. Each is linked with YTHDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDC1-to-partner and partner-to-YTHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by YTHDC1-low versus YTHDC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC1→partner) and Y-score (partner→YTHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.369	+2.178	.044	.035	3	2
COAD	XBP1 →	+0.244	+2.820	.006	.035	3	2
UCEC	ACC1 →	+0.289	+2.598	.012	.005	3	2
COAD	ASNS →	+0.604	+3.330	.001	.005	2	2
COAD	Cyclin-E1 →	+0.308	+2.820	.009	.035	3	1
UCEC	14-3-3_beta →	-0.082	-2.195	.010	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FASN by YTHDC1 expression — COAD

Explore this box plot interactively →