YTHDC1

Across TCGA cell cohorts, YTHDC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,539 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YTHDC1-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, mRNA destabilization, and Regulation of mRNA processing. Each is linked with YTHDC1 in more than 16 cancer types. Because this analysis shows association rather than direction, both YTHDC1-to-partner and partner-to-YTHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by YTHDC1-low versus YTHDC1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC1→partner) and Y-score (partner→YTHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of mRNA splicing, via spliceosome →	+0.107	+1.059	<.001	<.001	3	17
SOFT_TISSUE	mRNA destabilization →	+0.071	+0.797	<.001	.001	3	17
BLOOD_Lymphoma	Regulation of mRNA processing →	+0.089	+1.001	<.001	.002	3	17
URINARY_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.130	+0.561	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mRNA catabolic process →	+0.069	+0.695	<.001	.003	3	16
STOMACH	Negative regulation of myoblast fusion →	+0.090	+0.522	.001	.003	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,539 associations by consensus.

Regulation of mRNA splicing, via spliceosome by YTHDC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →