YTHDC1

Across TCGA cell cohorts, YTHDC1 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YTHDC1-associated genes across cancer lineages are C16orf78, BANF2, and USP29. Each is linked with YTHDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDC1-to-partner and partner-to-YTHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf78 grouped by YTHDC1-low versus YTHDC1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC1→partner) and Y-score (partner→YTHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C16orf78 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	BANF2 →	+0.035	+4.643	.003	.005	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.016	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CABS1 →	+0.012	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP10-3 →	+0.032	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

C16orf78 by YTHDC1 expression — BLOOD_Myeloma

Explore this box plot interactively →