YPEL5

Across TCGA patient cohorts, YPEL5 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YPEL5-associated genes across cancer lineages are A-Raf_pS299, GATA6, and ACC1. Each is linked with YPEL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both YPEL5-to-partner and partner-to-YPEL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by YPEL5-low versus YPEL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YPEL5→partner) and Y-score (partner→YPEL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.220	-3.000	<.001	.036	3	1
UCEC	GATA6 →	-0.171	-2.314	.027	.035	3	1
UCEC	ACC1 →	+0.429	+2.820	.018	.035	3	1
UCEC	INPP4B →	-0.331	-2.308	.041	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.245	-2.308	.003	.036	3	1
UCEC	JNK2 →	+0.247	+2.321	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

A-Raf_pS299 by YPEL5 expression — UCEC

Explore this box plot interactively →