YPEL1

Across TCGA patient cohorts, YPEL1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YPEL1-associated genes across cancer lineages are MAPK_pT202_Y204, Notch1, and PCNA. Each is linked with YPEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YPEL1-to-partner and partner-to-YPEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by YPEL1-low versus YPEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YPEL1→partner) and Y-score (partner→YPEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.511	-3.459	.015	.005	3	1
UCEC	Notch1 →	+0.142	+2.000	.025	.032	3	1
UCEC	PCNA →	+0.264	+2.321	.006	.033	3	1
UCEC	RAD51 →	+0.141	+3.169	.024	.019	3	1
UCEC	ATM →	-0.438	-3.169	.032	.019	3	1
UCEC	4E-BP1_pT37_T46 →	-0.370	-2.321	.028	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MAPK_pT202_Y204 by YPEL1 expression — UCEC

Explore this box plot interactively →