YME1L1

Across TCGA pan-cancer cohorts, YME1L1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated YME1L1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher YME1L1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated YME1L1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

HNSC, UCEC, and PCPG are the cancer types where YME1L1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.710	.001	45	view →
UCEC	DFS	Median	II,III,IV	1.000	0.299	.001	34	view →
PCPG	OS	Median	All	0.009	0.946	<.001	12	view →
STAD	DFS	Median	III,IV	1.000	0.466	.034	12	view →
LUSC	OS	Median	All	0.173	0.724	.012	6	view →
COAD	OS	Median	II,III,IV	0.547	0.852	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

YME1L1–HNSC (DFS)

Open the HNSC breakdown →