YME1L1

Across TCGA pan-cancer cohorts, YME1L1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of YME1L1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where YME1L1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types YME1L1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where YME1L1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YME1L1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.532	<.001	11	view →
LUAD	Male	III,IV	+0.535	<.001	9	view →
LSCC	Male	III,IV	+0.654	<.001	8	view →
HNSC	All	III,IV	+0.238	<.001	8	view →
OV	All	All	+0.435	<.001	2	view →
CCRCC	All	All	−0.099	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

YME1L1–COAD

Open the COAD breakdown →