YME1L1

Across TCGA patient cohorts, YME1L1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YME1L1-associated genes across cancer lineages are ASNS, ATM, and 14-3-3_beta. Each is linked with YME1L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both YME1L1-to-partner and partner-to-YME1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by YME1L1-low versus YME1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YME1L1→partner) and Y-score (partner→YME1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.321	+2.115	.005	.016	3	4
UCEC	ATM →	-0.448	-2.000	.001	.009	3	3
COAD	14-3-3_beta →	-0.183	-2.296	.047	.035	3	2
UCEC	eIF4E →	+0.157	+1.777	.019	.002	3	2
UCEC	A-Raf_pS299 →	-0.109	-3.087	.004	<.001	3	2
COAD	INPP4B →	-0.422	-3.450	.012	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ASNS by YME1L1 expression — UCEC

Explore this box plot interactively →