YJEFN3

Across TCGA cell cohorts, YJEFN3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YJEFN3-associated genes across cancer lineages are HTR5A, SMIM23, and UMOD. Each is linked with YJEFN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both YJEFN3-to-partner and partner-to-YJEFN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR5A grouped by YJEFN3-low versus YJEFN3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YJEFN3→partner) and Y-score (partner→YJEFN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HTR5A →	+0.029	+4.409	.004	.005	3	1
BLOOD_Leukemia	SMIM23 →	+0.022	+5.569	<.001	.001	3	1
LUNG_NSCLC_LUAD	UMOD →	+0.006	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR9G4 →	+0.039	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10G4 →	+0.012	+5.228	<.001	.005	3	1
LARGE_INTESTINE	MS4A4A →	+0.208	+3.678	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HTR5A by YJEFN3 expression — BLOOD_Leukemia

Explore this box plot interactively →