YJEFN3

Across TCGA cell cohorts, YJEFN3 mutation is significantly associated with the mutation status of many other genes, with 1,489 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YJEFN3-associated genes across cancer lineages are MYRF, DPYD, and PCDHGA12. Each is linked with YJEFN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both YJEFN3-to-partner and partner-to-YJEFN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYRF grouped by YJEFN3-low versus YJEFN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YJEFN3→partner) and Y-score (partner→YJEFN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYRF →	+2.422	+4.050	.004	.004	1	3
BLOOD_Leukemia	DPYD →	+5.145	+5.145	<.001	<.001	1	3
BLOOD_Leukemia	PCDHGA12 →	+2.975	+3.794	.006	.006	1	2
BLOOD_Leukemia	GDF2 →	+4.560	+4.309	.007	.007	1	2
LARGE_INTESTINE	TRMT2A →	+4.329	+4.329	.001	.001	1	2
LARGE_INTESTINE	HNF1B →	+3.744	+4.044	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,489 associations by consensus.

MYRF by YJEFN3 expression — LARGE_INTESTINE

Explore this box plot interactively →