YIPF7

Across TCGA patient cohorts, YIPF7 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YIPF7-associated genes across cancer lineages are PDK1_pS241, EGFR, and MEK1. Each is linked with YIPF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both YIPF7-to-partner and partner-to-YIPF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by YIPF7-low versus YIPF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YIPF7→partner) and Y-score (partner→YIPF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.195	+2.183	.030	.035	3	2
UCEC	EGFR →	-0.186	-3.321	.026	.010	3	1
UCEC	MEK1 →	+0.409	+3.321	.032	.010	3	1
UCEC	Tuberin →	+0.402	+3.009	.004	.019	3	1
UCEC	Caspase-8 →	-0.259	-3.169	.049	.019	2	1
UCEC	Chk2_pT68 →	-0.219	-3.321	.024	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PDK1_pS241 by YIPF7 expression — UCEC

Explore this box plot interactively →