YIPF5

Across TCGA patient cohorts, YIPF5 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YIPF5-associated genes across cancer lineages are A-Raf_pS299, Gab2, and ACC1. Each is linked with YIPF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both YIPF5-to-partner and partner-to-YIPF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by YIPF5-low versus YIPF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YIPF5→partner) and Y-score (partner→YIPF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.198	-3.169	<.001	.019	3	1
UCEC	Gab2 →	+0.440	+2.584	.008	.011	3	1
UCEC	ACC1 →	+0.377	+2.820	.026	.035	3	1
UCEC	JNK2 →	+0.400	+3.700	<.001	.001	3	1
UCEC	Ku80 →	+0.347	+2.598	.001	.006	3	1
UCEC	P-Cadherin →	-0.159	-3.311	.018	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

A-Raf_pS299 by YIPF5 expression — UCEC

Explore this box plot interactively →