YIPF4

Across TCGA pan-cancer cohorts, YIPF4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated YIPF4 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher YIPF4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated YIPF4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where YIPF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.930	0.642	.002	39	view →
UCEC	OS	Quartile	All	1.000	0.833	.012	18	view →
CCRCC	DFS	Median	III,IV	0.399	0.734	.006	16	view →
GBM	OS	Tertile	All	0.338	0.609	.002	10	view →
LUAD	DFS	Median	II,III,IV	0.920	0.791	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

YIPF4–HNSC (DFS)

Open the HNSC breakdown →