YIPF3

Across TCGA patient cohorts, YIPF3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YIPF3-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and GSK-3a-b_pS21_S9. Each is linked with YIPF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both YIPF3-to-partner and partner-to-YIPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by YIPF3-low versus YIPF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YIPF3→partner) and Y-score (partner→YIPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.129	-2.973	.007	.035	3	1
UCEC	EGFR_pY1068 →	-0.323	-2.459	.007	.020	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.496	+2.179	.016	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.265	+2.999	.007	.035	3	1
UCEC	SETD2 →	-0.227	-2.459	.030	.020	3	1
UCEC	Tuberin_pT1462 →	+0.280	+2.179	.012	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by YIPF3 expression — UCEC

Explore this box plot interactively →