YES1

Across TCGA pan-cancer cohorts, YES1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of YES1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where YES1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types YES1 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where YES1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YES1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.602	<.001	12	view →
HNSC	Male	IV	+0.452	<.001	11	view →
COAD	Male	II,III,IV	−0.274	<.001	11	view →
LUAD	Female	II,III,IV	−0.619	<.001	9	view →
LSCC	All	All	−0.235	<.001	6	view →
PDAC	All	All	+0.207	.016	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

YES1–CCRCC

Open the CCRCC breakdown →