YES1

Across TCGA patient cohorts, YES1 mutation is significantly associated with the RNA expression of many other genes, with 2,972 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YES1-associated genes across cancer lineages are RNU6-1298P, PANO1, and RNA5SP344. Each is linked with YES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YES1-to-partner and partner-to-YES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1298P grouped by YES1-low versus YES1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YES1→partner) and Y-score (partner→YES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1298P →	+0.308	+7.954	<.001	.008	3	2
UCEC	PANO1 →	+0.341	+2.763	.001	.002	3	2
LUSC	RNA5SP344 →	+0.394	+5.882	<.001	.002	3	2
UCEC	ERFL →	+0.326	+2.209	.002	.001	3	2
UCEC	MAPK12 →	+0.705	+2.069	<.001	<.001	3	2
UCEC	FAM83G →	+0.454	+1.545	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,972 associations by consensus.

RNU6-1298P by YES1 expression — HNSC

Explore this box plot interactively →