YES1

Across TCGA patient cohorts, YES1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YES1-associated genes across cancer lineages are PDCD4, ASNS, and Caspase-7-cleavedD198. Each is linked with YES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YES1-to-partner and partner-to-YES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by YES1-low versus YES1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YES1→partner) and Y-score (partner→YES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.562	-2.906	<.001	.001	3	2
UCEC	ASNS →	+0.431	+2.087	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.706	+1.505	<.001	.034	3	2
UCEC	EGFR_pY1068 →	-0.195	-1.321	.020	.029	3	1
UCEC	ERK2 →	+0.161	+1.362	.012	.034	3	1
UCEC	GAPDH →	+0.399	+1.415	.026	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PDCD4 by YES1 expression — UCEC

Explore this box plot interactively →