YES1

Across TCGA cell cohorts, YES1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,406 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible YES1-associated GO terms across cancer lineages are Nuclear pore organization, Regulation of centrosome duplication, and Negative regulation of macrophage colony-stimulating factor signaling pathway. Each is linked with YES1 in more than 12 cancer types. Because this analysis shows association rather than direction, both YES1-to-partner and partner-to-YES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear pore organization grouped by YES1-low versus YES1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YES1→partner) and Y-score (partner→YES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear pore organization →	+0.125	+1.143	<.001	<.001	3	13
BREAST	Regulation of centrosome duplication →	+0.080	+1.204	.001	.001	3	12
URINARY_TRACT	Negative regulation of macrophage colony-stimulating factor signaling pathway →	+0.220	+1.458	<.001	.001	3	11
LUNG_NSCLC_LUSC	Regulation of mitochondrial transcription →	+0.132	+1.198	.002	.001	3	11
BREAST	Regulation of chromosome segregation →	+0.097	+0.860	<.001	<.001	3	11
LARGE_INTESTINE	7-methylguanosine mRNA capping →	+0.085	+1.075	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,406 associations by consensus.

Nuclear pore organization by YES1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →