YEATS2

Across TCGA patient cohorts, YEATS2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YEATS2-associated genes across cancer lineages are ATM, Cyclin-E1, and PCNA. Each is linked with YEATS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both YEATS2-to-partner and partner-to-YEATS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by YEATS2-low versus YEATS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YEATS2→partner) and Y-score (partner→YEATS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.561	-1.857	<.001	<.001	3	3
COAD	Cyclin-E1 →	+0.290	+3.708	.005	<.001	3	3
BRCA	PCNA →	+0.230	+3.000	.030	.038	3	2
BRCA	Snail →	-0.222	-2.993	.028	.038	3	2
SKCM	Chk1 →	+0.195	+1.619	.019	.041	3	2
UCEC	eEF2 →	+0.241	+1.362	.022	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ATM by YEATS2 expression — UCEC

Explore this box plot interactively →