YEATS2

Across TCGA cell cohorts, YEATS2 mutation is significantly associated with the RNA expression of many other genes, with 238 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YEATS2-associated genes across cancer lineages are RBP3, TOX2, and CCR8. Each is linked with YEATS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YEATS2-to-partner and partner-to-YEATS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBP3 grouped by YEATS2-low versus YEATS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YEATS2→partner) and Y-score (partner→YEATS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RBP3 →	+0.016	+3.339	<.001	<.001	3	2
LARGE_INTESTINE	TOX2 →	+1.138	+3.364	.007	.002	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	GPR139 →	+0.043	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUSC	UMOD →	+0.006	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	SLC15A5 →	+0.006	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 238 associations by consensus.

RBP3 by YEATS2 expression — BLOOD_Leukemia

Explore this box plot interactively →