YEATS2-AS1

Across TCGA pan-cancer cohorts, YEATS2-AS1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated YEATS2-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher YEATS2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated YEATS2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LAML show a favorable association.

KIRC, MESO, and THCA are the cancer types where YEATS2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.446	0.731	<.001	138	view →
MESO	OS	Median	All	0.269	0.487	<.001	60	view →
THCA	OS	Median	II,III,IV	0.902	1.000	<.001	48	view →
UCS	OS	Median	II,III,IV	0.567	0.239	.004	48	view →
UCEC	DFS	Median	All	0.571	0.710	<.001	46	view →
CESC	DFS	Tertile	II,III,IV	0.329	0.826	<.001	44	view →
ACC	DFS	Median	All	0.432	0.775	.002	36	view →
KICH	DFS	Tertile	All	0.742	1.000	.008	35	view →
LIHC	DFS	Quartile	All	0.393	0.596	<.001	34	view →
KIRP	DFS	Median	All	0.366	0.716	.004	29	view →
PRAD	DFS	Median	All	0.832	0.934	<.001	28	view →
LAML	DFS	Quartile	All	0.527	0.272	.010	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

YEATS2-AS1–KIRC (DFS)

Open the KIRC breakdown →