YBX3

Across TCGA pan-cancer cohorts, YBX3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated YBX3 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher YBX3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated YBX3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

CCRCC, PDAC, and OV are the cancer types where YBX3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.603	0.893	<.001	32	view →
PDAC	DFS	Median	II,III,IV	0.475	0.266	.011	11	view →
OV	DFS	Tertile	All	0.608	1.000	.036	4	view →
UCEC	OS	Tertile	All	1.000	0.887	.036	2	view →
LSCC	DFS	Median	II,III,IV	0.970	0.863	.045	1	view →
LUAD	DFS	Median	All	0.893	1.000	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

YBX3–CCRCC (DFS)

Open the CCRCC breakdown →