YBX3

Across TCGA cell cohorts, YBX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YBX3-associated GO terms across cancer lineages are Calcium-dependent activation of synaptic vesicle fusion, Formate biosynthetic process, and Positive regulation of synaptic vesicle membrane organization. Each is linked with YBX3 in more than 6 cancer types. Because this analysis shows association rather than direction, both YBX3-to-partner and partner-to-YBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-dependent activation of synaptic vesicle fusion grouped by YBX3-low versus YBX3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YBX3→partner) and Y-score (partner→YBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Calcium-dependent activation of synaptic vesicle fusion →	-1.102	-1.354	<.001	.007	3	7
LUNG_SCLC	Formate biosynthetic process →	+0.106	+2.762	<.001	<.001	3	7
STOMACH	Positive regulation of synaptic vesicle membrane organization →	-1.102	-1.354	<.001	.007	3	7
STOMACH	Positive regulation of synaptic vesicle fusion to presynaptic active zone membrane →	-1.102	-1.354	<.001	.007	3	7
LUNG_SCLC	Cellular hyperosmotic response →	+0.161	+3.139	.002	.003	3	7
BREAST	Regulation of pentose-phosphate shunt →	+0.109	+1.584	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,117 associations by consensus.

Calcium-dependent activation of synaptic vesicle fusion by YBX3 expression — STOMACH

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