YBX2

Across TCGA patient cohorts, YBX2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YBX2-associated genes across cancer lineages are Fibronectin, HSP70, and N-Cadherin. Each is linked with YBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YBX2-to-partner and partner-to-YBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by YBX2-low versus YBX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YBX2→partner) and Y-score (partner→YBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.453	-3.584	.004	.002	3	1
UCEC	HSP70 →	-0.407	-2.459	.036	.020	3	1
UCEC	N-Cadherin →	-0.258	-3.159	.011	.019	3	1
UCEC	p90 RSK →	+0.209	+3.009	.023	.019	3	1
UCEC	Syk →	+0.454	+3.598	.012	.001	3	1
UCEC	Caspase-7-cleavedD198 →	+0.648	+3.019	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Fibronectin by YBX2 expression — UCEC

Explore this box plot interactively →