YBX1

Across TCGA pan-cancer cohorts, YBX1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated YBX1 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher YBX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated YBX1 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

CCRCC, LUAD, and OV are the cancer types where YBX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.571	0.847	.018	18	view →
LUAD	DFS	Median	All	0.521	0.878	.012	9	view →
OV	DFS	Median	All	0.577	0.942	.008	8	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
HNSC	OS	Median	II,III,IV	1.000	0.953	.019	5	view →
PDAC	OS	Quartile	II,III,IV	0.598	0.309	.031	2	view →
LSCC	OS	Tertile	II,III,IV	0.833	0.547	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

YBX1–CCRCC (DFS)

Open the CCRCC breakdown →