YBX1

Across TCGA patient cohorts, YBX1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YBX1-associated genes across cancer lineages are Bax, eEF2, and EGFR_pY1068. Each is linked with YBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YBX1-to-partner and partner-to-YBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by YBX1-low versus YBX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YBX1→partner) and Y-score (partner→YBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.203	+1.594	.031	.042	3	2
UCEC	eEF2 →	+0.441	+2.502	.001	.002	3	1
UCEC	EGFR_pY1068 →	-0.332	-3.169	<.001	<.001	3	1
UCEC	eIF4E →	+0.189	+2.584	.022	.010	3	1
UCEC	ERK2 →	+0.256	+2.502	<.001	.002	3	1
UCEC	GAPDH →	+0.472	+2.459	.025	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Bax by YBX1 expression — UCEC

Explore this box plot interactively →