YARS2

Across TCGA patient cohorts, YARS2 mutation is significantly associated with the RNA expression of many other genes, with 493 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YARS2-associated genes across cancer lineages are RNA5SP411, COQ5, and GCH1. Each is linked with YARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YARS2-to-partner and partner-to-YARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by YARS2-low versus YARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YARS2→partner) and Y-score (partner→YARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.242	+2.031	<.001	.007	3	2
UCEC	COQ5 →	+0.377	+3.374	.006	.004	3	2
UCEC	GCH1 →	+0.715	+2.839	.002	.001	3	2
UCEC	NARS1 →	+0.496	+2.807	.006	.003	3	2
BRCA	LINC01047 →	+0.088	+5.347	<.001	.006	3	2
UCEC	GLOD4 →	+0.473	+3.470	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 493 associations by consensus.

RNA5SP411 by YARS2 expression — UCEC

Explore this box plot interactively →