YARS2

Across TCGA patient cohorts, YARS2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YARS2-associated genes across cancer lineages are IGFBP2, MEK1, and Notch1. Each is linked with YARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YARS2-to-partner and partner-to-YARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by YARS2-low versus YARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YARS2→partner) and Y-score (partner→YARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.917	-2.999	.003	.035	3	1
UCEC	MEK1 →	+0.415	+3.169	.018	.019	3	1
UCEC	Notch1 →	+0.211	+3.179	.001	.010	3	1
UCEC	ATM →	-0.682	-2.459	.001	.020	3	1
UCEC	Beclin →	+0.109	+2.459	.017	.020	3	1
UCEC	CD20 →	+0.163	+2.189	.010	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

IGFBP2 by YARS2 expression — UCEC

Explore this box plot interactively →